Read about how researchers across the world are using QIAGEN Digital Insights solutions to accelerate their work in a variety of applications
Making sense of complex 'omics data, and developing the infrastructure to compile, store, search, analyze and visualize relevant information has significant challenges and may pose a burden to researchers without bioinformatics skills. Yet powerful insights derived from 'omics data help innovate, integrate and translate scientific results into impactful discoveries. Many noteworthy papers cite QIAGEN Digital Insights solutions and demonstrate how our tools help drive research insights and discoveries. These papers use QIAGEN Ingenuity Pathway Analysis (IPA), QIAGEN CLC Genomics and/or QIAGEN OmicSoft to help drive success. The QIAGEN Digital Insights portfolio encompasses a comprehensive, easy-to-use toolbox that ensures continuity in the NGS workflow. Here, we have curated a selection of just a few recent papers to offer a sense of the diversity of the research for which QIAGEN Digital Insights solutions makes a difference.
Multi-organ proteomic landscape of COVID-19 autopsies
First author: Xui Nie
Check out this fantastic work by coronavirus researchers at Westlake University who try to understand how SARS-CoV-2 causes cellular damage in organs other than the lungs. See how the team uses QIAGEN IPA to identify upregulated molecules and activated pathways in this proteomic study of COVID-19 autopsy samples. Read their full paper here.
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
First author: Marco Trizzino
Monocytes or macrophages? See how the team at The Wistar Institute used QIAGEN IPA to understand how EGR1 drives immune cell differentiation by studying upstream regulators of the genes associated with EGR1. Read the full article here.
Wastewater-based epidemiology as a useful tool to track SARS-CoV-2 and support public health policies at the municipal level in Brazil
First author: Tatiana Prado
We’ve heard wastewater can be used for COVID-19 surveillance. Check out this QIAGEN CLC research paper on wastewater-based epidemiology as a useful tool to track SARS-CoV-2 in Brazil. Read the full article here.
KLF10 deficiency in CD4+ T cells triggers obesity, insulin resistance and fatty liver
First author: Akm Khyrul Wara
Is immune dysregulation and obesity/insulin resistance connected? Researchers at Harvard Medical use QIAGEN IPA and QIAGEN CLC Genomics to study the role of CD4+ T cells in insulin resistance and obesity to reveal how KLF10, a transcription factor and a critical regulator of CD4+ T regulatory cells, maybe be responsible. Read the full article here.
Single-cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
First author: Amy J. Wisdom
Does immunotherapy work differently in primary vs. transplanted tumors? See how cancer researchers at Duke University use QIAGEN OmicSoft Suite for single-cell analysis of immune cells found in transplant vs. primary tumors and how these cells play a role in the effectiveness of immunotherapy. Read the full paper here.
Get in touch with us, we would love to hear from you. To request information on our QIAGEN Digital Insight solutions, contact bioinformaticssales@qiagen.com.
Read about how researchers across the world are using QIAGEN Digital Insights solutions to accelerate their work in a variety of applications
Making sense of complex 'omics data, and developing the infrastructure to compile, store, search, analyze and visualize relevant information has significant challenges and may pose a burden to researchers without bioinformatics skills. Yet powerful insights derived from 'omics data help innovate, integrate and translate scientific results into impactful discoveries. Many noteworthy papers cite QIAGEN Digital Insights solutions and demonstrate how our tools help drive research insights and discoveries. These papers use QIAGEN Ingenuity Pathway Analysis (IPA), QIAGEN CLC and/or QIAGEN OmicSoft to help drive success. The QIAGEN Digital Insights portfolio encompasses a comprehensive, easy-to-use toolbox that ensures continuity in the NGS workflow. Here, we have curated a selection of just a few recent papers to offer a sense of the diversity of the research for which QIAGEN Digital Insights solutions makes a difference.
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
First author: Yuki Shibayama
Did you know on average pancreatic cancer patients acquire over 67 non-synonymous mutations? The team at Kagawa University used QIAGEN IPA to study the role of (pro)renin receptor [(P)RR] in causing genomic instability. Read their full paper here.
Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling
First author: Katerina Lawlor
Did you know cancer cells are not only good at proliferating but can also suppress other cells from growing? See how the team at Imperial College London investigates this phenomenon using QIAGEN IPA to understand how cancer cells induce quiescence in glioblastomas. Read their full paper here.
Multiparametric profiling of engineered nanomaterials: Unmasking the surface coating effect
First author: Audrey Gallud
Discover this fascinating research by scientists at the Karolinska Institutet who study the cytotoxic effects of engineered nanomaterials (ENMs). See how the team uses QIAGEN IPA to understand the mechanism behind the cytotoxic effects of ENMs and how to mitigate the risks. Read the full article here.
Innate immune training of granulopoiesis promotes anti-tumor activity
First author: Lydia Kalafati
Check out this exciting research by L. Kalafati and colleagues at TU Dresden, who try to promote the anti-tumor activity of trained neutrophils. See how the team uses QIAGEN IPA to understand the molecular mechanism behind reprogramming caused by trained immunity agonists. Read the paper here.
Liver-expressed cd302 and cr1l limit hepatitis C virus cross-species transmission to mice
First author: Richard J. P. Brown
Did you know the hepatitis C virus (HCV) affects 71 million people worldwide but only infects humans? Read how researchers at Paul Ehrlich Institute (PEI) use QIAGEN IPA and QIAGEN CLC Genomics Workbench to understand how mice are able to prevent HCV infection. Read their full paper here.
Vascular disease and thrombosis in SARS-CoV-2-infected rhesus macaques
First author: Malika Aid
Is there a connection between thrombosis and SARS-CoV-2 infection? Read how the team at Beth Israel Deaconess Medical Center uses QIAGEN IPA to understand the critical interactions between various pathways that lead to SARS-CoV-2-induced blood clotting in rhesus macaques. Read their full paper here.
Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
First author: Benjamin Meckiff
Check out this critical coronavirus research by B. Meckiff and colleagues at the La Jolla Institute for Immunology, who study the role of CD4+ T cells in COVID-19. See how the team uses QIAGEN IPA to understand how different subsets of CD4+ T cells play a role in pathogenic immune responses to SARS-CoV-2 infection. Read the full article here.
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models
First author: Michael R. Garvin
Can mutations in coronavirus spike proteins help it escape current vaccines? See how a group at Oak Ridge National Laboratory predicts mutational hotspots in the viral genome using QIAGEN CLC Genomics and AI models. Read the full article here.
Genomic evidence for reinfection with SARS-CoV-2: A case study
Co-author: Joel Sevinsky
Is SARS-COV-2 reinfection possible? Joel Sevinsky and his colleagues in the Nevada public health arena report the first SARS-Cov-2 reinfection case in the US. See how the team uses QIAGEN CLC Genomics Workbench for bioinformatics analysis of their SARS-CoV-2 samples to discover whether it was the same virus or a genetically different specimen. Read the full article here.
Two distinct immunopathological profiles in autopsy lungs of COVID-19
First author: Ronny Nienhold
Is unlocking differences in immune response the key to treating ARDS in COVID-19? Dig into this important coronavirus research from R. Nienhold and colleagues at Cantonal Hospital Baselland who study different immunopathological profiles in COVID-19 patients. See how the team uses QIAGEN CLC Genomics Workbench to understand the different immune patterns observed in post mortem COVID-19 lung tissue. See their full article here.
A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
First author: Sarah R. Leist
Did you know coronaviruses are responsible for three epidemics in the 21st century? Great work by S. Leist and colleagues at the University of North Carolina at Chapel Hill, who created a mouse-adapted SARS-CoV-2 to understand the virus better. See how the team uses QIAGEN CLC Genomics Workbench to characterize this animal model and discover mechanisms for SARS-CoV-2 pathogenesis to test potential therapeutics. Read their full paper here.
Single-cell transcriptomics implicate novel monocyte and T cell immune dysregulation in sarcoidosis
First author: Lori Garman
Single-cell analysis improves our understanding of multimodal diseases. Don't miss this exciting cancer research by L. Garman and colleagues, who study the role of immune cells in sarcoidosis. The team uses QIAGEN IPA and QIAGEN OmicSoft DiseaseLand to identify dysregulated pathways using single-cell analysis. Read the full paper here.
Non-human primate blood–brain barrier and in vitro brain endothelium: From transcriptome to the establishment of a new model
First author: Catarina Chaves
Congratulations to the researchers at Sanofi for publishing their findings on a comparative model for the human blood-brain barrier (hBBB). See how the team uses QIAGEN IPA and QIAGEN OmicSoft Studio to investigate the transcriptome of brain capillaries from a non-human primate, and compare it to the hBBB. Read the full paper here.
Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs
First author: Saee Paliwal
Do we need better models for validating preclinical drug target candidates? How can we test these models? Read how researchers at BenevolentAI use QIAGEN OmicSoft DiseaseLand to evaluate the robustness of their computational model, Rosalind. Read the full paper here.
Get in touch with us! To request information on our QIAGEN Digital Insight solutions, contact bioinformaticssales@qiagen.com.
Researchers across the world are using QIAGEN Digital Insights solutions to accelerate their work in a variety of applications
Powerful insights help innovate, integrate and translate scientific results into impactful discoveries. Many noteworthy papers cite QIAGEN Digital Insights solutions and demonstrate how our tools help drive research insights and discoveries. These papers use QIAGEN Ingenuity Pathway Analysis (IPA), QIAGEN CLC and/or QIAGEN OmicSoft to help drive success. The QIAGEN Digital Insights portfolio encompasses a comprehensive, easy-to-use toolbox that ensures continuity in NGS workflow. Here, we have curated a selection of just a few recent papers to offer a sense of the diversity of the research for which QIAGEN Digital Insights solutions makes a difference.
Next-generation sequencing profiles of the methylome and transcriptome in peripheral blood mononuclear cells of rheumatoid arthritis
First author: Chia-Chun Tseng
In honor of World Autoimmune Arthritis Day (May 20), check out this exciting research by C. Tseng and colleagues from Kaohsiung Medical University who use next-generation sequencing to understand how the methylome and transcriptome contribute to rheumatoid arthritis. Learn how they use QIAGEN IPA to investigate the interaction between genetics and epigenetics. Dig into their research paper here.
Interferon-β corrects massive gene dysregulation in multiple sclerosis: Short-term and long-term effects on immune regulation and neuroprotection
First author: Xuan Feng
Excellent research by Xuan Feng and colleagues at the University of Chicago who study the effects of interferon-β on correcting gene dysregulation in multiple sclerosis. Discover how the team uses QIAGEN IPA to investigate the short-term and long-term impact of IFN-β on immune regulation and neuroprotection. Check out their research here.
Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons
First author: Emily M. A. Lewis
Dr. E. Lewis and colleagues from Washington University School of Medicine attempt to model multiplex autism using iPS cells derived from a family with autism. Learn how the team uses QIAGEN IPA to uncover the significance of unique genetic signatures contributing to polygenic autism. Read their paper here.
Pathogenic pathways in early-onset autosomal recessive Parkinson's disease discovered using isogenic human dopaminergic neurons
First author: Tim Ahfeldt
Fascinating research by Dr. T. Ahfeldt and colleagues at the Icahn School of Medicine at Mount Sinai who try to understand the pathogenic pathways involved in early-onset autosomal recessive Parkinson's disease. See how they use QIAGEN IPA to understand the significance of these pathways in causing Parkinson’s in isogenic human pluripotent stem cell lines. Read their research here.
Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
First author: Raphael Hesse
Exciting Research by R. Hesse and Colleagues at the University of Edinburgh who start and end with QIAGEN NGS solutions from Sample to Insight. See how the QIAamp DNA Mini Kit helps extract DNA from brain tissue and how QIAGEN IPA helps the team understand the pathways involved in Alzheimer’s disease pathophysiology. Delve into the details in their paper here.
Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
First author: Ursula K. Rohlwink
Tuberculous meningitis is the most severe form of TB with a high mortality rate. See how U. Rohlwink and colleagues at the University of Cape Town use QIAGEN IPA to help understand how the disease affects different compartments of the brain differently and cause neurotoxicity. Read the full Nature Communications article here.
De novo variants in exomes of congenital heart disease patients identify risk genes and pathways
First author: Cigdem Sevim Bayrak
Genetically heterogeneous diseases such as congenital heart disease (CHD) are ideally suited for pathway analysis to identify statistically significant key genes and their role in the disease pathogenesis. In this study, Bayrak and colleagues leverage QIAGEN IPA’s ability to take variant data from CHD patients to identify enriched pathways and develop a prioritized list of genes. Read the paper here.
Multi-'omics approach for studying tears in treatment-naïve glaucoma patients
First author: Claudia Rossi
Researchers use QIAGEN IPA to analyze the tears of glaucoma patients in this multi-'omics study aimed at better understanding primary open-angle glaucoma (PAOG). The team performed metabolomics and proteomics analyses to identify potential biomarkers that could help screen for this disease, which is the leading cause of irreversible blindness. Read the paper here.
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
First author: Edmund C. Lee
A team from Regulus Therapeutics use QIAGEN IPA to identify an anti-miRNA as a possible therapeutic in the treatment of autosomal dominant polycystic kidney disease (ADPSK), which is generally caused by mutations in PKD1 or PKD2. Discover how the team leveraged QIAGEN IPA’s extensive database of molecular interactions and biological findings to develop putative gene networks and pathways from gene expression data comparing disease data against their anti-microRNA treatment. Read the full Nature Communications paper here.
The circadian clock mutation promotes intestinal dysbiosis
First Author: Robin M. Voigt
Getting a good night’s sleep may be more important than you think. Fascinating research by Dr. R. Voight and colleagues at Rush University looks at the connection between sleep and intestinal dysfunction. Discover how the team uses QIAGEN IPA to tease out the relationship between the circadian rhythm and intestinal hyperpermeability. Read the full paper here.
Compromised metabolic reprogramming is an early indicator of CD8+ T cell dysfunction during chronic Mycobacterium tuberculosis infection
First author: Shannon L Russell
In honor of World Tuberculosis Day, check out this important research from the Africa Health Research Institute (AHRI) in Durban. They use QIAGEN IPA to look at how compromised metabolism can cause subpar T cell immunity against tuberculosis, and how pharmacological agents can help. Read the paper here.
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
First author: Shaza B Zaghlool
Fascinating research by Dr. S. Zhaglool and colleagues at Weill-Cornell Medical College in Qatar, where they look at the connection between epigenetics and proteomics in an epigenome-wide study. See how the team uses QIAGEN IPA to understand the connection between DNA methylation and blood circulating proteins involved with inflammation control. Read the full Nature Communications article here.
Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins
First author: Tommy Tsan-Yuk Lam
Coronavirus researchers from Hong Kong University use QIAGEN extraction kits and QIAGEN CLC Genomics Workbench to identify SARS-CoV-2 in Malayan pangolins. Their research helps reveal how pangolins may have facilitated the coronavirus transfer to humans, causing the COVID-19 disease. Read their Nature publication here.
Influenza A viruses are transmitted via the air from the nasal respiratory epithelium of ferrets
First author: Mathilde Richard
In honor of Global Hand Hygiene Day, remember to wash your hands! Check out this paper by researchers at Erasmus University Medical Center, who use QIAGEN CLC Genomics Workbench to investigate how influenza and other respiratory viruses are transmitted from nasal tracts using ferrets as a model. Read their full paper in Nature Communications.
Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018
First author: Yangun Wang
Learn about the critical research by Dr. Y. Wang and team from Guangzhou Medical University who studied a subgenotype of human coronavirus, NL63. They used QIAGEN CLC Genomics Workbench to investigate how this virus undergoes continuous mutation and has the potential to cause severe lower respiratory tract infection in humans. Read their research here.
Discovery of bat coronaviruses through surveillance and probe capture-based next-generation sequencing
First author: Bei Li
Dr. B. Li and colleagues from Wuhan Institute of Virology have been observing bats for potential coronavirus outbreaks after the SARS and MERS incidents. With the current pandemic, better surveillance practices are necessary to predict and mitigate the emergence of these viruses in humans. See how the team uses QIAGEN CLC Genomics Workbench and QIAGEN extraction kits in a capture-based NGS approach to overcome cost challenges. Discover their research here.
The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages
First author: Kelsi O. West
Great research from Texas A&M HSC where K. West and colleagues look at how pre-mRNA splicing decisions influence or are affected by macrophage activation. See how they use QIAGEN CLC Genomics and QIAGEN IPA to understand this link to the innate immune response in this Cell reports paper.
Microbiota dysbiosis and its pathophysiological significance in bowel obstruction
First author: Shrilakshmi Hedge
April is IBS awareness month. Check out this intriguing research by S. Hegde and colleagues from UTMB who look at how bowel obstruction may cause changes to the gut microbiota composition. See how the team utilizes a complete Sample to Insight approach using QIAGEN's extraction kits for bacterial DNA and RNA and QIAGEN CLC Microbial Genomics Module to identify bacterial species affected
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signaling
First author: Thomas Aga Legøy
Exciting research from the University of Bergen, where a team uses every part of the QIAGEN RNA-seq solution from Sample to Insight. See how QIAGEN CLC Genomics Workbench, QIAGEN IPA and other QIAGEN products help the team understand the development process of human-induced pluripotent stem cells into pancreatic islet cells. You can access the full Scientific Reports paper here.
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
First author: Ryoko Araki
Crucial research for cell replacement therapy by Dr. R. Araki and colleagues from the National Institute of Radiological Sciences (NIRS) in Japan where they study how point mutations in reprogrammed pluripotent stem cells prevent their therapeutic application. Learn how the team uses QIAGEN CLC Genomics Workbench to understand how a cell cycle checkpoint deficiency causes a cancer-like state in these cells. Read the full Nature Sciences article here.
Immunomodulatory activity of humanized anti–IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes
First author: Kevan C. Herold
Diabetes breakthrough research by Dr. K Herold and team in collaboration with Pfizer at the Yale School of Medicine who used a humanized monoclonal antibody to block cytokine IL-7, which is critical for T cell development and function. Learn how the team used QIAGEN OmicSoft Array Suite to investigate how blocking IL-7 affects immune cells and could help treat diabetes. Get the details by accessing the full paper here.
Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex
First author: Takatoshi Hikida
Hikida and colleagues at Osaka University try to tease out the molecular connections between different regions of the brain. Learn how the team uses QIAGEN OmicSoft Suite and QIAGEN IPA to understand how knocking down gene expression of D1 and D2 receptors in the neurons of the nucleus accumbens affects gene expression in the neurons of the medial prefrontal cortex. Get the details in this Scientific Reports paper.
Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes
First author: Rebecca Riise
A team at AstraZeneca use QIAGEN OmicSoft DiseaseLand to help them study the role of bleomycin hydrolase in inflammation and wound healing. Find out how they discover a novel role for this cysteine protease in the regulation of cytokine secretion. Read this Scientific Reports paper here.
To request information on the QIAGEN Digital Insight solutions, contact bioinformaticssales@qiagen.com.
