We’re excited to reveal many new improvements and enhancements to the latest release of QIAGEN CLC Genomics Workbench and its related plugins that significantly extend its value. Key improvements and new features in the new version (v24) include:
Figure 1. RNA-Seq volcano plot shows the relationship between fold changes and p-values. The reworked volcano plot allows for 1) different color gradients for positive and negative fold change values, 2) annotations, 3) legends and 4) customizable transparency of data points. Genes of interest can also be highlighted by setting thresholds.
Figure 2. Visualize and interact with spatial transcriptomics data.
Learn more about the applications supported by our portfolio of QIAGEN CLC Genomics software and request a consultation with one of our experts to help you find the right QIAGEN CLC toolset for your research goals.
Discovering new genes implicated in hereditary diseases or cancer progression is challenging yet advancing rapidly due to the increase in next-generation sequencing (NGS) cohort data. These data analyses produce insights into associations between gene variants and diseases and the biological mechanisms of these gene variants.
By combining QIAGEN CLC Genomics Workbench, QCII-T and QIAGEN IPA, you can analyze sequencing data obtained from a variety of NGS technologies, annotate gene variants using the world’s most comprehensive and up-to-date curated scientific evidence and find biological connections in gene variants with manually curated scientific findings. Using a streamlined NGS analysis workflow, you’ll get valuable and reliable insights for your research project and speed up your discoveries.
In this training, you’ll:
1. Learn to import whole genome or exosome sequencing data into QIAGEN CLC Genomics Workbench and use the ultra-fast LightSpeed Module that delivers an end-to-end NGS FASTQ to VCF pipeline
2. Explore the capabilities in QCII-T which can help accelerate your discoveries from hereditary or tumor cohort analyses to find associations between gene variants and diseases
3. Learn how to use QIAGEN IPA and its manually curated content, among other integrated scientific evidence, to uncover novel biological mechanisms underlying these gene variants
Advances in next-generation sequencing (NGS) technologies over the years have significantly decreased the cost of whole genome (WGS) and whole exome (WES) applications, such that they are considered the standard of care within multiple healthcare organizations. Arguably, the most significant NGS challenges lie within data analysis and interpretation. Various parameters such as sensitivity, specificity, cost and speed are critical for secondary analysis, while accurate, comprehensive and up-to-date content is required for reliable interpretation. These aspects are crucial, especially where rapid turnaround times are critical for improved health outcomes. There is no better example than the implementation of WES and WGS in the neonatal and pediatric intensive care units (NICU/PICU).
Join this webinar to learn about QIAGEN CLC LightSpeed, a secondary analysis software that dramatically reduces the cost and time it takes to analyze WES and WGS data and generate actionable insights.
Key learning objectives
Who should attend?
Bioinformaticians, Geneticists, Lab managers, NGS technicians, researchers, and biologists
It’s exciting that advancements in high-throughput sequencing techniques and analysis enable us to generate whole genome (WGS) and whole exome (WES) data in bulk for many species, including humans. With new machines and chemistries, the cost of sequencing has decreased significantly. However, the total cost of ownership associated with bioinformatic analysis of the resulting files remains a bottleneck (1).
Whether you run a genome center, testing facility, core lab or provide sequencing services, you’ve got to deliver variant call files (VCFs) at an unbeatable price and with consistent quality and turnaround time, even at peak demand. Your customers, as well as your business, depend on it. Many high-speed NGS analysis solutions require purchasing expensive, highly specialized hardware, massive computers or large cloud computing contracts. The requirement for fast and consistent turnaround times, also at peak demand, can quickly translate into a need for more personnel, more processing power—and more investment. How do you keep costs down yet deliver quality results with quick turnaround in a world of shrinking budgets?
More investment in your bioinformatics infrastructure? Nope—now you don’t have to
What if there were a scalable, point-and-click solution that could handle all your WGS, WES and large panel data analysis needs without having to purchase vast amounts of specialized infrastructure? A software that could run with a GUI and be used by anyone with minimal training? What if you didn’t have to compromise between speed and quality?
Introducing a better, faster, cheaper and more flexible tool for WGS and WES analyses
Our all-in-one NGS bioinformatics software QIAGEN CLC Genomics Workbench Premium now offers you a faster, more accurate, more flexible and more affordable way to process WGS and WES files in bulk. This is made possible via QIAGEN CLC LightSpeed Module, which enables an ultra-fast and accurate FASTQ to VCF pipeline for hereditary germline mutation analysis.
What’s more, you’ll enjoy full flexibility. Our QIAGEN CLC Genomics Workbench Premium can process data from any sample, any panel and any species and run your analyses on a laptop, desktop, server or the cloud without depending on any new or specialized hardware.
Reduce cost with speed: Accelerate WGS secondary analysis down to just 25 mins
For certain licenses, you only pay an annual fee for software access, allowing you to run (and re-run) as many samples as you need. And because of our ultra-fast FASTQ to VCF pipeline, you can get more analyses done in less time. This translates into lower analysis costs, both for on-premise and cloud deployment.
In our recent benchmark study, we showed that using our ultra-fast QIAGEN CLC LightSpeed technology our FASTQ to VCF hereditary workflow analyzes 34x human WGS samples in just 25 minutes, whereas a QIAseq Exome v3 50x sample takes just 90 seconds. When run in Amazon Web Services (AWS), the incurred computing costs were about $1 per WGS and a few cents per WES. There is no other technology that can process WGS or WES this fast—or as cost-efficient.
With demonstrated high accuracy and reproducibility, and built on a scalable bioinformatics analysis platform, QIAGEN CLC LightSpeed technology will revolutionize your ability to perform high-volume whole genome sequencing.
A software that’s ‘cheaper than free’
QIAGEN CLC Genomics Workbench Premium is an NGS analysis software your core lab can’t do without. It enables you to deliver ultra-fast sequencing analysis results while controlling your costs. It does this by saving your lab time, processing capacity and energy, so you can provide affordable services. You’ll also enjoy a variety of specialized tools for all your sequencing needs. The CLC platform software QIAGEN CLC Genomics Server and QIAGEN CLC Genomics Cloud Module help you to build the scalable bioinformatics analysis architecture you need to offer a high-throughput genomics analysis service at affordable prices. In addition, our QIAGEN CLC Genomics platform is fully supported with tutorials and documentation, an excellent team of customer support professionals and dedicated trainers to ensure you have the support you need to perform your analyses. These advantages result in reduced total cost of ownership and are far cheaper than maintaining your current setup. Therefore transitioning to QIAGEN CLC Genomics Workbench Premium is a switch you’ll quickly discover is ‘cheaper than free’.
Get in touch
Learn more about the newest features of QIAGEN CLC in our latest release, check out our upcoming webinar and request a consultation from one of our experts. Ready to try it out for yourself? Request a trial of QIAGEN CLC Genomics Workbench Premium to see how this software will make it faster, easier and cheaper for you to analyze your NGS data.
Share your CLC LightSpeed results and win
Got killer runtime results using QIAGEN CLC LightSpeed? Share them with us on social media using #CLCLightSpeed. When you do, you'll enter for a chance to win one of three one-year licenses to QIAGEN CLC Genomics Workbench Premium. You may alternatively enter for a chance to win by submitting the online entry form available here. Terms and conditions apply.
References
We’re excited to reveal many new improvements and enhancements to the latest release of QIAGEN CLC Genomics Workbench and its related plugins that significantly extend its value. Key improvements and new features in the new version 23 (v23) include:
Figure 1. An array of visualizations now available in QIAGEN CLC Genomics Workbench version 23.0.
Learn more about the applications supported by our portfolio of QIAGEN CLC Genomics software, and request a consultation with one of our experts to help you find the right QIAGEN CLC toolset for your research goals.
