As you may remember, six months ago COSMIC launched new, improved beta download files. These new files contain the same gold standard data found in COSMIC's current files, but presented in a more accessible and interoperable manner. COSMIC aims to to lead by example in encouraging data to be FAIR (Findable, Accessible, Interoperable and Reusable) compliant, and as part of this goal, COSMIC will be phasing out its current files for COSMIC v100. We want to help make this transition as smooth as possible, so keep reading to find out what changes have been made, why they've been made, and how these changes will benefit you.
These new files have been named "Beta" to help you distinguish them from the files you are used to, but they represent the final version and the content and layout are stable.
We will be phasing out current file formats in May 2024 in line with release v100, meaning that, we will be retiring our current download files and only the new style files will be available to download.
With this in mind, here’s how the COSMIC team is helping to ease this transition:
→ Get the details on COSMIC's latest release here.
We are pleased to announce the availability of a new release for COSMIC, the Catalogue of Somatic Mutations in Cancer. COSMIC Actionability v9 adds new actionability data to the world’s largest, expert-curated somatic mutation database. The release includes 5 new fully curated somatic genes, 948 new clinical trials, and 100 new oncology drugs.
In this article, we provide a summary of the COSMIC Actionability v9 release highlights.
COSMIC, the Catalogue of Somatic Mutations in Cancer, is an expert-curated database encompassing the wide variety of somatic mutation mechanisms causing human cancer. Owned and maintained by the Wellcome Sanger Institute, COSMIC is exclusively licensed through QIAGEN.
COSMIC’s team of variant scientists manually curates key cancer genes to provide in-depth information on mutation distributions and effects. The team relies on a semi-automated curation process of cancer genomes to provide broad somatic annotations toward target discovery and identification of patterns and signatures. To date, COSMIC contains nearly 24 million somatic mutations associated with human cancers.
COSMIC Actionability is a standalone product within the COSMIC database that focuses on providing information on the availability and development of drugs targeting somatic mutations in cancer. COSMIC’s certified curation team integrates data from case studies, clinical trials, and regulatory bodies to represent a full picture of the current precision oncology pipeline (from drug development, through safety and clinical phases, to market and repurposing).
Actionability contains information on three core units: mutations, diseases and drugs. By capturing relations between these units, COSMIC’s team identifies existing and upcoming drugs that target specific genetic variants in different cancer types. COSMIC Actionability is a cutting-edge, ‘living-tool’ that provides the most up-to-date data for precision oncology applications.
→ View the full Actionability v9 release notes here.
Learn more about COSMIC and how the industry-leading database can help you identify biomarkers, annotate variants, and explore the etiology of human cancers here.
See first-hand how COSMIC can be used in your lab by downloading sample data here.
